ISSN : 2319-7323




INTERNATIONAL JOURNAL OF COMPUTER SCIENCE ENGINEERING


Open Access

ABSTRACT

Title : RAPID AND SENSITIVE DOT MATRIX METHODS FOR GENOME ANALYSIS
Authors : Dr.M.Manimekalai, S.Regha
Keywords : Dot – Plots and Scoring Matrices, Importance of scoring matrices, Similarity versus Distance, Similarity Versus Homology, Global Versus Local Similarity, Simple Sequence Repeats(SSR’s)
Issue Date : July 2015
Abstract : Dot – matrix plots are widely used for similarity analysis of biological sequences. Many algorithms and computer software tools have been developed for this purpose. Two dot-matrix comparison methods have been developed for analysis of large sequences. The methods initially locate similarity regions between two sequences using a fast word search algorithm, followed with an explicit comparison on these regions. The methods produce high quality dot-matrix plots with low background noise. Space requirements are linear, so the algorithms can be used for comparison of genome size sequences. Simple sequence repeats(SSR) or micro-satellites are becoming standard DNA markers for plant genome analysis and are being used as markers in marker assisted breeding.De novo generation of micro-satellite markers through laboratory-based screening of SSR-enriched genomic libraries is highly time consuming and expensive. A tandem repeat in DNA is two or more adjacent, approximate copies of a pattern of nucleotides. Tandem Repeats Finder is a program “to locate and display tandem reports in DNA sequences”. In order to use the program, the user submits a sequence in FASTA format.
Page(s) : 113-115
ISSN : 2319-7323
Source : Vol. 4, No.4